Nucleoside plus nucleotide analogs and cessation of hepatitis B immunoglobulin after liver transplantation in chronic hepatitis B is safe and effective
نویسندگان
چکیده
منابع مشابه
Mutations at Nucleotide 1762, 1764 and 1766 of Hepatitis B Virus X Gene in Patients with Chronic Hepatitis B and Hepatitis B-Related Cirrhosis
Abstract Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...
متن کاملRelationship between hepatitis B DNA Viral load in the liver and it\'s histology in patient with chronic hepatitis B
Background: Serial measurement of hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods: Thirty patients with chronic anti-Hbe positive ...
متن کاملEntecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues.
BACKGROUND The combination of entecavir, a nucleoside analogue, and adefovir, a nucleotide analogue, would be a promising salvage treatment for chronic hepatitis B (CHB) patients who fail nucleoside/nucleotide analogue (NA) regimens. METHODS A total of 89 CHB patients who had failed NA regimens and were treated with entecavir plus adefovir combination for at least 12 months were included. R...
متن کاملNew Nucleoside Analogs for the Treatment of Chronic Hepatitis B
Three agents have been approved for the treatment of chronic hepatitis B virus (HBV): interferon-alpha, lamivudine and adefovir. Each agent has certain limitations and none has an excellent efficacy. Lamivudine and adefovir have the advantages of oral administration and excellent safety profiles. However, optimal treatment of chronic hepatitis B is still under debate. The sustained response rat...
متن کاملIs Hepatitis B Immunoglobulin Necessary in Prophylaxis of Hepatitis B Recurrence after Liver Transplantation? A Meta-Analysis
BACKGROUND & AIMS Application of nucleoside analogues and hepatitis B immunoglobulin (HBIG) has reduced hepatitis B virus (HBV) recurrence rate after liver transplantation (LT) dramatically. Recent data suggests therapy without HBIG is also effective. We sought to evaluate the necessity of HBIG in prophylaxis of HBV recurrence after LT. METHODS A meta-analysis was performed. PubMed/MEDLINE, W...
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ژورنال
عنوان ژورنال: Journal of Clinical Virology
سال: 2013
ISSN: 1386-6532
DOI: 10.1016/j.jcv.2013.06.035